論文リスト(~2010)

Paumen MB, Ishida Y, Muramatsu M, Yamamoto M, Honjo T.
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.
J Biol Chem. 1997 Feb 7;272(6):3324-9.

Paumen MB, Ishida Y, Han H, Muramatsu M, Eguchi Y, Tsujimoto Y, Honjo T.
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2.
Biochem Biophys Res Commun. 1997 Feb 24;231(3):523-5.

Muramatsu M, Sankaranand VS, Anant S, Sugai M, Kinoshita K, Davidson NO, Honjo T.
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
J Biol Chem. 1999 Jun 25;274(26):18470-6.

Kanazawa N, Nakamura T, Tashiro K, Muramatsu M, Morita K, Yoneda K, Inaba K, Imamura S, Honjo T.
Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.
Eur J Immunol. 1999 Jun;29(6):1925-32.

Muto T, Muramatsu M, Taniwaki M, Kinoshita K, Honjo T.
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
Genomics. 2000 Aug 15;68(1):85-8.

Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T.
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Cell. 2000 Sep 1;102(5):553-63.

Revy P, Muto T, Levy Y, Geissmann F, Plebani A, Sanal O, Catalan N, Forveille M, Dufourcq-Labelouse R, Gennery A, Tezcan I, Ersoy F, Kayserili H, Ugazio AG, Brousse N, Muramatsu M, Notarangelo LD, Kinoshita K, Honjo T, Fischer A, Durandy A.
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
Cell. 2000 Sep 1;102(5):565-75.

Kinoshita K, Lee CG, Tashiro J, Muramatsu M, Chen XC, Yoshikawa K, Honjo T.
Molecular mechanism of immunoglobulin class switch recombination.
Cold Spring Harb Symp Quant Biol. 1999;64:217-26. Review.

Muramatsu M, Honjo T.
Complex layers of genetic alteration in the generation of antibody diversity.
Trends Immunol. 2001 Feb;22(2):66-8.

Kinoshita K, Harigai M, Fagarasan S, Muramatsu M, Honjo T.
A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs.
Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12620-3.

Fagarasan S, Kinoshita K, Muramatsu M, Ikuta K, Honjo T.
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria.
Nature. 2001 Oct 11;413(6856):639-43.

Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Nature. 2001 Dec 6;414(6864):660-5.

Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.
J Exp Med. 2002 Feb 18;195(4):529-34.

Honjo T, Kinoshita K, Muramatsu M.
Molecular mechanism of class switch recombination: linkage with somatic hypermutation.
Annu Rev Immunol. 2002;20:165-96. Epub 2001 Oct 04. Review.

Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T.
The AID enzyme induces class switch recombination in fibroblasts.
Nature. 2002 Mar 21;416(6878):340-5.

Bross L, Muramatsu M, Kinoshita K, Honjo T, Jacobs H.
DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.
J Exp Med. 2002 May 6;195(9):1187-92.

Yoshikawa K, Okazaki IM, Eto T, Kinoshita K, Muramatsu M, Nagaoka H, Honjo T.
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.
Science. 2002 Jun 14;296(5575):2033-6.

Fagarasan S??, Muramatsu M??, Suzuki K, Nagaoka H, Hiai H, Honjo T. *These two authors contribute equally to this work.
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.
Science. 2002 Nov 15;298(5597):1424-7.

Doi T, Kinoshita K, Ikegawa M, Muramatsu M, Honjo T.
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2634-8.

Zhu Y, Nonoyama S, Morio T, Muramatsu M, Honjo T, Mizutani S.
Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase.
J Med Dent Sci. 2003 Mar;50(1):41-6.

Okazaki I, Yoshikawa K, Kinoshita K, Muramatsu M, Nagaoka H, Honjo T.
Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation.
Ann N Y Acad Sci. 2003 Apr;987:1-8.

Okazaki IM, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, Honjo T.
Constitutive expression of AID leads to tumorigenesis.
J Exp Med. 2003 May 5;197(9):1173-81.

Harada Y, Muramatsu M, Shibata T, Honjo T, Kuroda K.
Unmutated immunoglobulin M can protect mice from death by influenza virus infection.
J Exp Med. 2003 Jun 16;197(12):1779-85.

Ta VT, Nagaoka H, Catalan N, Durandy A, Fischer A, Imai K, Nonoyama S, Tashiro J, Ikegawa M, Ito S, Kinoshita K, Muramatsu M, Honjo T.
AID mutant analyses indicate requirement for class-switch-specific cofactors.
Nat Immunol?@ 2003 Sep;4(9):843-8.

Eto T, Kinoshita K, Yoshikawa K, Muramatsu M, Honjo T.
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12895-8.

Suzuki K, Meek B, Doi Y, Muramatsu M, Chiba T, Honjo T, Fagarasan S.
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut.
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1981-6.

Ito S, Nagaoka H, Shinkura R, Begum N, Muramatsu M, Nakata M, Honjo T.
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1975-80.

Honjo T, Muramatsu M, Fagarasan S.
AID: how does it aid antibody diversity?
Immunity. 2004 Jun;20(6):659-68.

Shinkura R, Ito S, Begum NA, Nagaoka H, Muramatsu M, Kinoshita K, Sakakibara Y, Hijikata H, Honjo T.
Separate domains of AID are required for somatic hypermutation and class-switch recombination.
Nat Immunol. 2004 Jul;5(7):707-12.

Nasim A. Begum, Kazuo Kinohsita, Naoki Kakazu, Masamichi Muramatsu, Hitoshi Nagaoka, Reiko Shinkura, Detlev Biniszkiewicz, Laurie A.
Boyer, Rudolf Jaenisch, and Tasuku Honjo
“Uracil DNA glycosylase activity is dispensable for immunoglobulin
class switch “
Science 2004 Aug 20; 305(5687):1160-3

Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC.
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo.
Cell. 2004 Aug 20;118(4):431-8.

Begum NA, Kinoshita K, Muramatsu M, Nagaoka H, Shinkura R, Honjo T.
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13003-7.

Alugupalli KR, Leong JM, Woodland RT, Muramatsu M, Honjo T, Gerstein RM.
B1b lymphocytes confer T cell-independent long-lasting immunity.
Immunity. 2004 Sep;21(3):379-90.

Nagaoka H, Ito S, Muramatsu M, Nakata M, Honjo T.
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase.
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2022-7.

Kotani A, Okazaki IM, Muramatsu M, Kinoshita K, Begum NA, Nakajima T, Saito H, Honjo T.
Target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4506-11.

Honjo T, Nagaoka H, Shinkura R, Muramatsu M.
AID to overcome the limitations of genomic information.
Nat Immunol. 2005 Jul;6(7):655-61. Review.

Junt T, Fink K, Forster R, Senn B, Lipp M, Muramatsu M, Zinkernagel RM, Ludewig B, Hengartner H.
CXCR5-Dependent Seeding of Follicular Niches by B and Th Cells Augments Antiviral B Cell Responses.
J Immunol. 2005 Dec 1;175(11):7109-16.

Wakae K, Magor BG, Saunders H, Nagaoka H, Kawamura A, Kinoshita K, Honjo T, Muramatsu M.
Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.
Int Immunol. 2006 Jan;18(1):41-7.

Muto T, Okazaki IM, Yamada S, Tanaka Y, Kinoshita K, Muramatsu M, Nagaoka H, Honjo T.
Negative regulation of activation-induced cytidine deaminase in B cells.
Proc Natl Acad Sci U S A.2006 Feb 21;103(8):2752-7

Tasuku Honjo, Masamichi Muramatsu, Hitoshi Nagaoka, Kazuo Kinoshita, and Reiko Shinkura
AID to overcome the limitations of genomic information by introducing somatic DNA alterations
Proceeding of the Japan Academy, Series B 2006 March 82(3):104-119

Wang J, Shinkura R, Muramatsu M, Nagaoka H, Kinoshita K, Honjo T.
Identification of a specific domain required for dimerization of activation-induced cytidine deaminase.
J Biol Chem. 2006 Jul 14;281(28):19115-23.

Kotani A, Kakazu N, Tsuruyama T, Okazaki IM, Muramatsu M, Kinoshita K, Nagaoka H, Yabe D, Honjo T.
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1616-20.

Muramatsu M, Nagaoka H, Shinkura R, Begum NA, Honjo T.
Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.
Adv Immunol. 2007;94:1-36.

Kovalchuk AL, duBois W, Mushinski E, McNeil NE, Hirt C, Qi CF, Li Z, Janz S, Honjo T, Muramatsu M, Ried T, Behrens T, Potter M.
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements.
J Exp Med. 2007 Nov 26;204(12):2989-3001.

Pasqualucci L, Bhagat G, Jankovic M, Compagno M, Smith P, Muramatsu M, Honjo T, Morse HC 3rd, Nussenzweig MC, Dalla-Favera R.
AID is required for germinal center-derived lymphomagenesis.
Nat Genet. 2008 Jan;40(1):108-12.

Sekiguchi Y, Ichikawa M, Takamoto M, Ota H, Koh CS, Muramatsu M, Honjo T, Agematsu K.
Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis.
Immunol Lett. 2009 Feb 21;122(2):145-9. Epub 2008 Sep 29.

Nonaka T, Doi T, Toyoshima T, Muramatsu M, Honjo T, Kinoshita K.
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2747-51. Epub 2009 Feb 5.

Higashi AY, Ikawa T, Muramatsu M, Economides AN, Niwa A, Okuda T, Murphy AJ, Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T,Yanagita M.
Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.
J Immunol. 2009 May 1;182(9):5633-40.

Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K, Honjo T.
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.
Proc Natl Acad Sci U S A. 2009 Dec 11.

Stanlie A, Aida M, Muramatsu M, Honjo T, Begum NA.
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22190-5.